The 20 most serious human epidemics and global pandemics
Original Owen Jarus Silk Road Heritage

During the global influenza pandemic in Spain in 1918, the influenza ward of the US military camp hospital in France. (Photo: Shutterstock)
In the long history, the outbreak of epidemic diseases always threatens mankind, sometimes changing the historical process and even marking the end of the whole civilization. Here, we have summarized the 20 most serious epidemics from prehistoric times to modern society.
1. Prehistoric Plague: Around 3000 BC

A room about 5,000 years ago was found in China, with debris all over it, or a deadly plague happened here. (Image copyright: China Archaeology)
About 5000 years ago, an infectious disease wiped out a prehistoric village in China. The room where the bodies of the deceased were piled up was then burned. The wreckage in the room belongs to teenagers, young people and middle-aged people, indicating that people of all ages have not been spared. This archaeological site, now known as Ha Min Mangha, is one of the best preserved prehistoric sites in Northeast China.
Archaeological and anthropological studies have found that the epidemic occurred very quickly. People don’t even have time to prepare a proper funeral. The site has not been inhabited since then.
Before the discovery of the site of Hamin Mangha, another large prehistoric tomb in Northeast China was unearthed in Miaozigou, which was almost at the same time. Together, these findings show that an epidemic disease once raged in the whole region.
2. Athens plague: 430 BC

Remains of Pantheon in Acropolis complex. The city experienced a plague lasting about five years around 430 BC. (Image copyright: Shutterstock)
Around 430 BC, a battle between Athens and Sparta had just begun, and the plague swept through Athens for five years. Some analysts estimate that the death toll is in the millions. Thucydides (460-400 BC), an ancient Greek historian, described it as follows: "People who are in good health are suddenly hit hard on the head, their eyes are red and swollen, their internal organs such as throat and tongue are congested, and their breathing is unnatural and full of stench." (Translated by Richard Crowley, quoted from the Peloponnesian War, Dent Press, London, 1914. )
The specific disease of this plague has been a controversial topic among scientists. A series of diseases, including typhoid fever and Ebola, are possible. Many scholars believe that the gathering phenomenon caused by the war may have worsened the situation of this plague. Because the Spartan army was stronger, the Athenians gathered in the city’s military protective building called "Long Wall" to seek refuge. The plague did not stop the war from continuing, and Athens was forced to surrender until 404 BC.
3. Anthony plague: 165-180 AD

Roman soldiers are likely to return home with smallpox virus, which will eventually lead to the outbreak of Anthony plague. (Image copyright: Shutterstock)
When the expedition soldiers returned to the Roman Empire, they brought back more than victory. According to the article published by Apropod, a senior professor of Roman history at Manchester Metropolitan University, in the book Ancient Upheavals (routledge Press, 2017), the plague of Anthony was most likely caused by smallpox virus. Since then, it has ravaged the army and killed more than 5 million people in the Roman Empire.
Many historians believe that the plague was brought back to the Roman Empire by soldiers after the war with Parthia. The plague finally led to the end of the peaceful Roman period, which lasted from 27 BC to 180 A.D. and the national strength once reached its peak. After 180 AD, turmoil spread throughout the Roman Empire. Not only did civil war break out, but "barbarians" also invaded from outside. Christianity became more popular after the plague broke out.
4. Plague in Cyprus: 250-271 AD

In Thebes, Egypt, victims of an ancient plague were burned by bonfires. (Image copyright: N Qiyang, ONLUS Egyptian and Sudanese Cultural Research Association)
The Archbishop of Carthage (the city of Tunisia) named Saint Cyprus described the epidemic as "the end of the world" because it killed about 5,000 people in Rome alone. In 2014, archaeologists discovered a large burial place for plague victims in Luxor. The bodies of the victims were covered with a thick layer of lime (used as a disinfectant in history). Archaeologists also found three kiln sites used to make lime, and traces of burning victims with bonfires.
Experts are not sure what disease caused the plague. "A common flu takes away the patient’s body energy after removing the intestinal resistance, and (at the same time) the high fever from the bone marrow leads to a wound in the throat (part of the mouth)", written by Cypriots in a Latin book called Death (Philip Schaff translated from the appendix of The Father of the Third Century: Hippolytos, Cyprus, Caius, Novatian, Christian Classics Library, 1885).
5. Justinian plague: 541-542 AD

Mosaic portraits of Justinian the Great and his supporters. (Image copyright: Shutterstock)
The Byzantine Empire declined under the attack of the Black Death. The plague then occurred intermittently. According to some speculations, more than 10% of the global population died.
The plague was named after the Byzantine monarch Justinian (ruling period: 527-565 AD). Under its rule, the Byzantine Empire reached its peak, controlling a large territory from the Middle East to Western Europe. Justinian ordered the construction of the famous Hagia Sophia (Holy Wisdom) Cathedral in the imperial capital Constanyine (today’s Istanbul). Justinian was also infected with the plague, but survived. However, its empire was constantly losing territory under the attack of the plague.
6. Black Death: 1346-1353 AD

The Chronicle of Nuremberg, Volume I, with illustrations CCLXIIII. Skeletons are rising from the dead and joining the dance of death. (Image copyright: Anton Keberg, 1493/Public Server)
From Asia to Europe, the Black Death brought destruction all the way. Some studies estimate that half of the European population died. The Black Death was caused by an extinct strain of Yersinia pestis, which spread through fleas and infected rats. The bodies of the victims are generally buried together.
This plague profoundly changed the course of European history. Due to the large number of deaths, the labor force plummeted, the wages of workers were raised, and the European serfdom system ended. Research shows that the surviving laborers can get more meat and better quality bread. The shortage of cheap labor may also promote technological innovation.
7. The Great Plague of Coco Rizzitelli: 1545-1548.

Aztec ruins national monument. (Image copyright: USGS US Geological Survey)
The plague in Cocoa Rizzitelli was caused by a combined infection with viral hemorrhage and high fever, which eventually killed 15 million people in Mexico and Central America. As the local population has been hit by extreme drought before, the disease has become particularly deadly. "Coco Rizzitelli" means "pest" in Aztec.
A new study examined the DNA in the remains of the deceased and found that they were infected by a subspecies of Salmonella called Salmonella paratyphi C. This pathogen brings intestinal fever common to common typhoid patients. Intestinal fever causes high fever, dehydration and other gastrointestinal problems, which is a major disease threat even today.
8. American plague: 16th century

Hernan cortese and his army painted by O Graff (1892). After the Spanish invaders captured the Aztec city, they let it suffer from smallpox. (Image copyright: Shutterstock)
Plague in America refers to a series of European pandemics brought to America by European explorers. These epidemics, including smallpox, accelerated the collapse of Inca civilization and Aztec civilization. Some studies estimate that nearly 90% of the indigenous population in the Western Hemisphere died.
To some extent, these epidemics helped the army led by Hernan cortese to conquer Diotihuacan, the capital of Aztec, in 1519, and Francisco Pizarro’s army to capture Inca in 1532. The Spanish thus occupied the territory of the two empires. The Aztec and Inca armies were unable to resist Spanish arms because of the disease. Britain, France, Portugal and the Netherlands, in the process of exploring, raiding and settling in the Western Hemisphere, also benefited from the sudden decline of local resistance caused by the epidemic to some extent.
9. Great Plague in London: 1665-1666

London fire model in 1666. The fire happened just after the city suffered a deadly plague. (Image copyright: Shutterstock)
The last outbreak of the Black Death occurred in Great Britain. It then led to a large-scale migration led by Charles II. The plague began in April 1665 and spread rapidly in the hot summer. Infecting fleas on rats is the main channel for spreading the virus. At the end of the plague, about 1 million people died, including 15% of the population in London. But this is not the end of this ordeal. On September 2, 1666, the fire in London spread and burned a large area of the city for four days.
10. Marseilles plague: 1720-1723

Today, France’s St. Jane’s Castle, Meyer Cathedral and Marseilles Old Port. About 30% of the Marseille population died in a plague that lasted for three years in the 1720s. (Image copyright: Shutterstock)
Historical records show that the great plague in Marseilles originated from a ship named Saint Anthony that docked in the harbor. The ship returned with cargo from the eastern Mediterranean. Although the ship was immediately isolated, the plague still entered the city. The most likely reason is fleas carried by infected rats.
The plague spread rapidly, causing about one million deaths in Marseille and its vicinity in the following three years. It is estimated that 30% of the population of Marseille lost their lives.
11. Russian plague: 1770-1772

Portrait of Catherine II painted by Virgilius Erickson (about 1757-1772). Even Queen Catherine could not lead Russia out of the devastating blow caused by the plague in 1770. (Image copyright: Shutterstock)
In Moscow after the plague, the fear of isolated residents turned into violence. Riots spread in the city, which eventually led to the murder of Archbishop Amplo Theseus, who advised parishioners not to gather for prayer.
Empress Catherine II of Russia (also known as Catherine the Great) desperately needed to control the plague and rebuild social order, so she hastily ordered all factories to move to Moscow. When the plague ended, about one million people died. Although the plague is over, the reconstruction process of the queen is in jeopardy. In 1773, Ye Liewan pugachev claimed to be Peter III (the executed husband of yekaterina) and launched a riot, resulting in thousands of deaths.
12. Philadelphia yellow fever: 1793

George Washington’s second inauguration ceremony, Philadelphia Congress, March 4, 1793. A plague of yellow fever swept through Philadelphia in the first half of 1793. (Image copyright: Shutterstock)
When yellow fever swept through Philadelphia, the capital of the United States at that time, abolitionists advocated African-Americans to take part in caring for the patients because of the official misunderstanding that slaves were immune.
The epidemic is spread by mosquitoes. It was hot and humid in Philadelphia that summer, and the number of mosquitoes soared. The epidemic did not end until the mosquitoes disappeared in the winter of the same year. More than 5,000 people were killed.
13. Global influenza pandemic: 1889-1890

Woodcut depicts Paris during the global influenza in 1889-1890. Nurses are taking care of patients. This global epidemic has killed about one million people. (Image copyright: Shutterstock)
In the era of modern industrialization, new traffic links make it easier for influenza virus to cause large-scale chaos. In just a few months, the disease spread all over the world, killing about one million people. In just five weeks, the death rate of epidemic disease reached its peak.
Case reports first appeared in Russia. Although air travel has not yet appeared, the virus spread rapidly in St. Petersburg and then spread throughout Europe and around the world.
14. American polio pandemic: 1916

Washington D.C., Franklin D. Roosevelt Memorial Hall. President Roosevelt was diagnosed with polio in 1921 at the age of 39. By the time Salk vaccine appeared in 1954, the pandemic had killed thousands of people. (Image copyright: Shutterstock)
A polio epidemic that started in new york eventually sickened 27,000 people and killed 6,000 people in the United States. The epidemic mainly affects children, and in some cases, it will lead to lifelong disability of survivors.
Polio occurred from time to time in the United States before Salk vaccine was developed in 1954. After the vaccine was widely vaccinated, the number of cases in the United States declined. The last report of polio in the United States was in 1979. Although it has not been completely eliminated, the effect of vaccine research and development around the world has greatly reduced the occurrence of this disease.
15. Spanish influenza: 1918-1920

Emergency Hospital during Influenza Epidemic, Camp Fenston, Kansas. (Image copyright: Oddis Historical Archives, National Museum of Health and Medicine)
It is estimated that 500 million people from south to NATO have become victims of Spanish flu. One fifth of them were killed, and some indigenous communities were almost extinct. Because the living space of soldiers was constrained during the First World War, ordinary people were malnourished during the war, and this flu was particularly contagious and fatal.
Although it was named Spanish flu, the epidemic did not originate in Spain. Spain was a neutral country during the war, and its press was not strictly censored, so it was free to report the situation in the early stage of the epidemic. As a result, people mistakenly thought that the epidemic mainly occurred in Spain, and the name Spanish flu continued.
16. Asian Influenza: 1957-1958

Chickens are tested for avian influenza. In 1950s, an avian flu killed about one million people. (Image copyright: Shutterstock)
Asian influenza is another global influenza pandemic. The epidemic originated in China and killed more than one million people. What caused the outbreak of the epidemic was an avian influenza virus.
According to CDC records, the disease spread rapidly, and cases appeared in Singapore in February 1957, Hong Kong in April 1957 and coastal cities in the United States in the summer of 1957. There are more than 1.1 million deaths worldwide and 116,000 cases in the United States.
17. Global and regional infectious diseases of AIDS: 1981-present.

AIDS became a global epidemic in 1980s, and then it continued to spread in some parts of the world. (Photo copyright: Mario Suriani/joint report, new york Historical Society)
Since the first confirmed case, AIDS has killed 35 million people around the world. It is very likely that the HIV virus that caused AIDS first spread among chimpanzees and spread to humans in West Africa in the 1920s. The virus spread all over the world, and AIDS developed into a global infectious disease at the end of the 20th century. Today, about 64% of the 40 million people in sub-Saharan Africa carry human immunodeficiency virus (HIV).
For decades, there has been no treatment for this disease. However, drugs developed in the 1990s can enable patients to live a normal life with regular treatment. Even more exciting, two HIV patients were cured in early 2020.
18. Global pandemic of H1N1 swine flu: 2009-2010

On April 30, 2019, at the Sartre Delta Medical Center in Antioch, California, a nurse passed a diversion tent built outside the emergency room. The hospital is preparing for the arrival of a large number of swine flu patients. (Image copyright: Justin Sullivan, Getty Images)
The outbreak of swine flu in 2009 originated from a new H1N1 strain that appeared in Mexico in the spring of 2009. According to the US Centers for Disease Control and Prevention, within one year, the virus infected about 1.4 billion people around the world, killing 151,700 to 575,400 people.
According to the US Centers for Disease Control and Prevention, the influenza pandemic in 2009 mainly targeted at children and young people, and about 80% of the dead people were under 65 years old. This is unusual because the mortality rate of most strains of influenza virus, including seasonal influenza, is mainly aimed at people over 65 years old. In the case of swine flu, the elderly may have developed enough immunity to the virus group to which H1N1 belongs, so they have not received too much influence. The vaccine against the H1N1 virus that causes swine flu has now been included in the annual influenza vaccine.
19. Ebola epidemic in West Africa: 2014-2016

During the Ebola outbreak in 2014, medical workers wore protective clothing before entering the Ebola treatment site in Liberia. (Image copyright: CDC/Sally ezra/Antalya Christie (Public Service))
The Ebola virus ravaged West Africa between 2014 and 2016, resulting in a total of 28,600 reported cases, of which 11,325 were killed. The earliest case was reported in Guinea in December 2013, and then the epidemic spread rapidly to Liberia and Sierra Leone. Cases and deaths mainly occurred in the above three countries. According to the report of the CDC, a few cases occurred in Nigeria, Mali, Senegal, the United States and Europe.
Even though efforts to develop vaccines continue, Ebola has not been effectively treated so far. The earliest known Ebola virus appeared in Sudan and Democratic Republic of Congo in 1976, and the virus may have originated from bats.
20. Zika virus epidemic: 2015 to present

Workers spray mosquitoes carrying Chika virus with pesticides. Chika virus is most common in tropical areas. (Image copyright: Shutterstock)
The impact of the recent Chika virus epidemic in South America and Central America is unknown. Meanwhile, scientists are racing against time to control the virus. Chika virus is generally transmitted by Aedes mosquitoes, but it can also be transmitted among humans through sexual intercourse.
Although Chika virus is generally harmless to adults and children, it can attack babies who are still in the womb and cause birth defects. Mosquito species carrying Chika virus are most likely to multiply in warm and humid climate, so South America, Central America and the southern United States have become the main areas for virus transmission.
Source: livescience
Translation: IICC-X Zhao Jinchao
Original title: "Understanding History: 20 Most Serious Diseases and Global Pandemic"
Read the original text